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“Although the research focused on a single person, it reverberated through the world of brain science and even got the attention of the (then) acting director of the National Institutes of Health, Lawrence Tabak. “Sometimes careful study of even just one truly remarkable person can lead the way to fascinating discoveries with far-reaching implications,” Tabak wrote in his blog post about the discovery.”

Very cool - they found an extended family in Medellin, Colombia where virtually everyone got early-onset Alzheimer’s. Except for one guy. Studying his genome revealed a variant related to Reelin, and subsequent studies suggest that Reelin is indeed neuroprotective.



There has been research that shows that "Reelin supplementation enhances cognitive ability..." - in mice at least.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166788/


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Not very funny. Making fun of people with disease? Show some class here, please.


Depends on your culture. In many places dealing with bad things humorously is preferred to being all stone-faced about them. One of my grandparents has dementia and since nobody can change that, the family generally tries to be light-hearted about it. Sure, it's tough for everyone involved, for those who he doesn't recognize, those who take care of him, and for himself, but there's no need to make it drag you down more than necessary. Imagine you're struggling with some condition that affects your every remaining waking moment and impedes your ability to interact with those around you, and everyone is all stone-faced about it to boot. Humor is a way to make the best out of a bad situation.

Everything has it's time and place of course, but this was one of the least-bad places one could've made that particular joke. Everyone knows dementia sucks, but for now it's an inevitability for many people. There's no need to make it worse by being all doom and gloom about it.


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Having watched what it did to family members, it's hard to me, personally, find any joke about Alzheimer's or dementia funny.

The structure and phrasing work to tickle the part of my mind that enjoys juxtaposition, though, so that was nice at least.


Society of the Mind has a section on humor (27.6) that poses a theory of humor (see also https://en.wikipedia.org/wiki/Theories_of_humor ) and jokes that I find somewhat persuasive.

One of the ways that we learn is "do X -> reward" and "don't do X -> no reward". But this is only training us one way - a positive way - about what is desirable.

How do you learn what is not desirable. "Don't touch the oven when its on" is something that you learn through "do Y -> punishment" ... but is there a "don't do Y -> reward" path that can be found? Is there a way to positively train the "don't do Y" paths?

    A mother says to her son "don't forget to sweep the corners."  The son replies "don't worry, I swept everything into the corner."
You are rewarded for laughing at that joke. Why? Because it is something that you shouldn't do. In this joke, we have expressed an undesirable state to be able to learn from in a rewarding way rather than a punishing way.

And somewhere, long ago, I recall a web page that had a short summary of each theory of humor and a joke that was not funny according to that theory. I doubt there will ever be a Grand Unified Theory of Humor.


Are there theories of humor that don't boil down to "setup expectation juxtaposed with punchline reality"? If there was ever a grand unified theory of humor, that would be my guess.


This would likely fall under the Incongruity Theory of humor where the mismatch of expectation and actual result with the punchline.

There's a song that I find rather funny. This is to be sung to the tune of M*A*S*H's theme.

    Through the upturned glass I see
    a modified reality--
    which proves pure reason kant critique
    that beer reveals das ding an sich--
(das ding an sich is Thing-in-itself which is the philosophical statement that things are what they are independent of observations).

Consider this video https://youtu.be/rUibuIDNANg - is it funny? If so, why? Would "laughing at the misfortune of others" be a better explanation than "setup of expectations and punchline?"

Or consider some of the many PBF Comics. Consider https://pbfcomics.com/comics/nude-beach/ (NSFWish - there are nipples). This falls more into the "sneaking past the censors of taboo" classification.

https://pbfcomics.com/comics/battleship/ (this one is safe for work) also doesn't fall into the "setup expectation" since, what is the expectation of a rat and a bat playing battleship? If it is "the first frame is funny because of incongruity - then why is the third frame funny?" Would https://pbfcomics.com/comics/sir-leopold/ be better described with relief theory?

I suspect that a selection of PBF comics would be an excellent test of "pick which theory of humor best describes {comic} and why" for a philosophy class. Is it relief? misfortune of others? benign violation?


C.S. Lewis condensed this even further, as the "sudden perception of incongruity."


To avoid accidentally stepping into qualia territory, please define "punchline".


Typically the line that reveals the juxtaposition itself, which is typically also the last line, or the last portion in the case of a one-liner.

https://en.m.wikipedia.org/wiki/Punch_line

Has a nice round up, though the section on the etymology of the term is a little disappointing.


How about this one then:

The scientists involved must have been pretty shocked by this discovery. You might say they were... Reelin from the implications.

Thank you, I'll be here all week. Try the veal!


zdrangnar said they arent offended so its okay


Some people use humor to cope with unpleasant things. No offense is intended.


Intended or not, people do get hurt by it.

We've all got different ways of handling it so the best we can hope for is some mutual compassion and thoughtfulness. One factor in that is to realize that the effect is more relevant than the intention.


Some people get hurt by normal everyday items and things. Trying to avoid hurting anyone turns you into a person who would hurt everyone.


> Trying to avoid hurting anyone turns you into a person who would hurt everyone.

Other than the citation needed, it is possible to avoid hurting _some_ people, with surprisingly minimal effort, even if you can never avoid hurting anyone ever.

The black-and-white argument you've presented - in its many forms of "if 100% outcome is not possible, it's worth 0% effort" - exists purely to absolve people of the responsibility to try.


At the same time, if someone says it hurts when you do this, "sorry, but things hurt people," leaves a lot to be desired.


Eh, I wouldn't go that far. The key to sensitive jokes is to know your audience. Throwing one out into a public forum isn't very likely to land, but in the right situation it might cheer up a person who is suffering from the very topic at hand.




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