I use codespaces and replit quite a lot. It's just very easy to work from anywhere and I spend quite a lot of time in VR (because it's convenient for me to work with large screens vs actually having large screens; also better battery life than my laptop).
Would love to know more about your VR setup. I can barely spend 20 mins with a headset before the dizziness and fatigue kicks in, and this is when playing games! I can't imagine working with a headset on.
When I work, it's with the (n/x)real, when we have a tech meeting, we use the Quest 2. The xreal, I haven't had any fatigue or issues and I have been using it fulltime for a year. The Quest 2, I don't notice any eye/brain issues, but it's just pulling on my head (and I have the comfort straps and extra balancing out battery, but it still starts hurting my head after about an hour. If it were lighter and more comfortable and AR and have better battery life, I would probably wear it fulltime. Maybe the quest 3 although battery life is not going to cut it I am sure. The huge advantage of the xreal is that it's just sunglasses; they are very light and your phone (or external device) is the driver; I use a beefy samsung phone and it basically means I have easily 15 hours of screen time before it starts whining about the battery.