When I work, it's with the (n/x)real, when we have a tech meeting, we use the Quest 2. The xreal, I haven't had any fatigue or issues and I have been using it fulltime for a year. The Quest 2, I don't notice any eye/brain issues, but it's just pulling on my head (and I have the comfort straps and extra balancing out battery, but it still starts hurting my head after about an hour. If it were lighter and more comfortable and AR and have better battery life, I would probably wear it fulltime. Maybe the quest 3 although battery life is not going to cut it I am sure. The huge advantage of the xreal is that it's just sunglasses; they are very light and your phone (or external device) is the driver; I use a beefy samsung phone and it basically means I have easily 15 hours of screen time before it starts whining about the battery.