I had to do a bit to manage to make work their search with my noscript/basic (x)html browser: they had cyberpunk work very nicely (silver) with one of the first versions of the game and an antique wine version 5.22.
Nothing about the latest wine 8.11 and latest version of cyberpunk 2077 on steam.
Horizon Zero Dawn seems to have a dx12 or a vulkan backend, and the EPIC(gog) is gold on wine 8.0 (since it does not have dx<=11).
I know that on complex software, "working" on a previous version does not mean working on the last, but it stays a good signal (same issue with proton).
As far as I used appdb, all entries I browsed seemed to be for vanilla wine (as it should be).
Don't forget that one of the killer features of vanilla wine: its SDK it only 2 small C compilers, an ELF one, and a COFF one. Namely, tinycc (ELF/COFF) should be sufficient.
I don't see a small C compiler as a feature of any importance really in this case. Especially if gaming is concerned. All relevant use cases support all needed compilers.