As far as I used appdb, all entries I browsed seemed to be for vanilla wine (as it should be).
Don't forget that one of the killer features of vanilla wine: its SDK it only 2 small C compilers, an ELF one, and a COFF one. Namely, tinycc (ELF/COFF) should be sufficient.
I don't see a small C compiler as a feature of any importance really in this case. Especially if gaming is concerned. All relevant use cases support all needed compilers.
Don't forget that one of the killer features of vanilla wine: its SDK it only 2 small C compilers, an ELF one, and a COFF one. Namely, tinycc (ELF/COFF) should be sufficient.