I'm really sorry to hear that. Since you're asking for moonshots and weird things to try, here's something they can ask their doctor about:

> Case reports involving glioblastoma patients using water-only fasting regimens in conjunction with other forms of cancer treatment have reported favorable outcomes with respect to tumor growth https://pmc.ncbi.nlm.nih.gov/articles/PMC2874558/ https://pmc.ncbi.nlm.nih.gov/articles/PMC5884883/

From https://pmc.ncbi.nlm.nih.gov/articles/PMC6836141/

I have a relative with glioblastoma who could see his granddaughter born if he extends his life a while. Thanks a lot for sharing!

You're welcome. I read a lot about fasting and I have a lot of experience with it. It's helped me, personally, heal many things (but not all of them -- it's good to have low expectations.) In any case, it's a mind-expanding experience to go without food for a while, regardless of the outcome.

Please Google Thomas Seyfried and William Makis. The latter is controversial—if he’s not completely fraudulent and making things up, he might be onto something. He’s sharing emails from numerous cancer patients who claim to have healed using these two particular molecules.

Exercise can supposedly help outcomes for some types of cancer—-I wonder whether the mechanism is similar to that of fasting. The supposed mechanism AIUI is that exercise makes less glucose available to the tumor. Podcast with more info here: https://overcast.fm/+6j6rLbfGM

There was an episode from “diary of a ceo” (don’t let the title fool you) where a scientist was making similar remarks:

https://youtu.be/VaVC3PAWqLk

I wouldn’t usually post these kind of things, but since OP is asking for moonshots i’ll take a chance.

Best of luck to your friend!

You still shouldn’t post that kind of thing. Especially not that fraudulent bullshitter host.

Thanks

steve jobs and many others tried things like that. if it makes you feel good then sure, but that alone will kill you faster when a tumor(s) gets out of control.

Love the drawings. Kind of a silly question, but how did you do them?

Excalidraw[0] and a mouse and a few failed attempts :)

[0] https://excalidraw.com/

How can someone tell if a newspaper is biased? What’s the test? Is it the eye test — as in, I can tell it when I see it — or something more?

Spoiler; every newspaper and media source is biased. They have to be. Starting with what stories they run and don't run and ending with the specific word choice they make inside the articles.

Critical thinking is the only thing you can use to spot bias. Compare and contrast different stories. Then make up your own mind.

Media literacy and virtual l critical reasoning should be the bedrock of modern education, and it is not.

A demagogue tells you so and then either you believe it or you become suspicious that their manipulation of you is the actual danger.

Then again: Should I trust a given medium just because somebody I don't trust tells me I shouldn't?

You're supposed to use a combination of your life experience and best judgment, which is as it always was. Extreme trust and extreme distrust are both irresponsible.

Your responsibility is to remember that institutions are made up of flawed people just like yourself, and work towards improving them. You don't let someone manipulate your emotions to turn them into abstract enemies, tear them down, and replace them with nothing.

I don’t see how someone at ~50/100 odds is predicted to win. That’s just a toss up with a slight statistical edge. Goes for both candidates.

I guess I'm cool coming out and saying it. Out of curiosity I bought some helminths online and infected myself. I was inspired to do it after reading a book called An Epidemic of Absence.

I can't say a whole lot -- positive or negative -- came from it, but it was easy to do and inexpensive. So even though the article says you shouldn't try it at home, I did. I consider it safe. I'm not a doctor, I just read a lot of PubMed, so take that for what it's worth.

Is the beta amyloid theory wrong? I read a review paper on this and the science was unclear. I think the point was that all AD patients had a pretty heavy amyloid burden, but not the converse. Feel free to send me some reading.

Nobody seems to be able to answer the key question whether it's a marker, or a driver.

I relate to the persona above you. I have plenty of hobbies, and almost all of them are free or cheap. I don't need a better laptop than what I have, I don't need an expensive bike to enjoy riding around, I don't need better running shoes -- or any shoes -- to go for a nice long run. The high of having the shiny new thing wears off.

Recently I got rid of my bed, entirely. I had an expensive latex mattress, but I realized I enjoy sleeping right on the floor. It's firmer, cooler, and easier to maintain. It's just one of the many cases where I realized that less was more.

Same here. My hobbies include learning languages, which thanks to the internet can be done for free. Same for reading research papers, programming stuff, etc. I walk instead of taking public transportation because I like it, it's free and good for health. I eat at home most of the time and depending on season I prefer meeting friends outside instead of going to a bat. The only thing I'm finding spending a bit too much on is cards (Magic, Pokémon), but it's still less than 100€/month on average.

On thing I noticed is that acquiring an object call for more objects. Let's say buying a new phone. It then need a case. The charger norm changed so an adaptator is need. We are already at 3 new objects instead of one, and all of that need to be stored somewhere (with may require a new box). I find myself more often than not taking pleasure into not buying things.

I always hated this because English is not so simple. To my eye, “me and him went to the store” or “him and me went to the store” both sound good to my ear. But “he and I went to the store” sounds slightly weird, and “I and he went to the store” just sounds awful. Which makes me think this rule is bogus, and that when you compose pronouns with “and”, English actually prefers the object case even when in the subject position. If it were as simple as the rule you suggest, the order of the pronouns would not matter. I’ve also heard people say (e.g.) “he did it with X and I” which makes me think “She and I” in the subject position (for example) is more of a prescriptive grammatical virus than actual English.

Wow. I really appreciate the humility and candor shown by you in response to being corrected. I’m genuinely impressed.

I'd like to see that, the studies I've seen show around 1-5% per year.

Is that trained or untrained? "Newbie gains" is a real thing, mostly caused by people going from a negative health state to a "normal" health state (or inactivity to basic activity).

I can see a rapid increase in untrained people but more marginal increases in trained people because of this.

I was under the impression newbie gains were more attributable to better neuromuscular and connective tissue adaptation rather than something that can lead to bone growth. You can gain like 2-4lbs of muscle per month in that phase, and a disproportionate amount of strength.

A 40% increase in bone density over 6 weeks sounds like someone’s DEXA scanner is broken. Bones just don’t change that quickly.

Is there a case of bone density being "too low" in some sense that can cause it to go up more quickly? Maybe it's not the bones themselves but something the DEXA scanner picks up that looks like bone growth?