Unlike most vaccines, there's no herd immunity benefit for humans because the transmission vector are ticks. So to make any headway we have to go after the ticks, and their hosts, the deer and the deer mouse.
I guess they can, but the wild animals are the primary disease reservoir, mostly just because there aren't all that many ticks feeding on humans and making it back into the wild.
It also matters what species egg laying females feed on. The first few paragraphs of this lay it out:
> In 1998 SmithKline Beecham (now GlaxoSmithKline) developed a vaccine that was about 80 percent effective for at least a year after three doses.
[1] http://www.nytimes.com/2013/09/19/opinion/bring-back-the-lym...