Apple's objective-c and associated framework were designed to be coded against (and even though it supports message passing, it still heavily uses parameterized sub-routines).

A lot of 3d modeling software provides frameworks where you hook things up instead of coding out solutions (Foundry Modo, Eyeon Fusion, Dynamo are a few). These are very domain specific and not designed to work as general purpose languages/frameworks.

We are working on some ideas for a general purpose compose-able framework and language that uses messages with behavior as the abstraction for communication between sub-systems (http://blog.interfacevision.com/design/design-composition-ba...).