Beta-carboline MAOI's were originally hypothesized to be what is important for those who feel something is missing with nicotine-only eliquid. After 3 years of working on this, I can tell you that this is not true. What's important is the other "minor tobacco alkaloids" like anatabine, anabasine, myosimine, etc.
Beta-carboline MAOI's, like the minor alkaloids, do have a potentiating effect with nicotine and therefore increase satisfaction or the potential for addiction; however, these MAOI's are pyrosynthesized (created by burning) 20-40x. This means that these MAOI's are not a significant component of a WTA eliquid or non-burned tobacco like the snus many people turn to for the "something missing".
Beta-carboline MAOI's, like the minor alkaloids, do have a potentiating effect with nicotine and therefore increase satisfaction or the potential for addiction; however, these MAOI's are pyrosynthesized (created by burning) 20-40x. This means that these MAOI's are not a significant component of a WTA eliquid or non-burned tobacco like the snus many people turn to for the "something missing".