I do. I dock it at home with a bigger screen/keyboard/mouse, so there it's just like another laptop/desktop. When I'm on the move, I bring my wireless mouse and the type cover. It works well enough for me. The screen is pretty small (obviously), but very high res, so I have as much screen real-estate, but with smaller fonts. My eye-sight is good so I have no problems with that. The keyboard is OK, but if I need to do a lot of work I much prefer a bigger one.

A huge plus for me that differentiates it from both laptops and iPads is the Wacom stylus, which has replaced all my (paper)notebooks at home and work.

To anyone considering to buy one I recommend going to a Microsoft store or Best Buy to try it out. Seems like a love it or hate it kinda product.