The last time I wrote assembly was for clock cycle accurate timing manipulating some IO pins at rates very near the limits of the processor. No time or tolerance for interrupt handlers and timers.

Before that it was to program a pair of limited range timers to run with slightly different periods so I could lazily read them from C, then by examining their phase and values determine if I got an uninterrupted pair of data, and if so, how many times the timers had rolled over, thus implementing a single, high resolution, extended range timer.

It is also used to exploit processor instructions which do not yet have compiler support.