I briefly used Axure and found it to be pretty solid. I know a lot of UX professionals that swear by it, but frankly it was not for me. For lo-fi prototypes, I still use paper. And, as I move into higher fidelity prototypes, I find it much easier to just code the prototype in HTML/CSS/JS. The primary benefit being that I can easily prototype responsive layouts without double (or triple) work, and the final product can be used as an input to the development process.
Thank you! I see the ability to communicate within the file (working assumptions, feedback and priorities) as a real pro. Also; I've tried html/css and as a designer I'm just not fast enough in it. I don't have the time to keep learning design, ui, ux and html/css. Axure looks like it allows me to concentrate on the user, the flow and the ui/design without worrying about the code and all the browser-stuff related to it. The generated prototyes allow for good testing.
My only cautionary advice is that it is becoming more common to see the UI/UX role to encompass design, HCI, and front-end development. You might be limiting yourself by having a narrow focus.
Thank you, I see a much bigger role for UI/UX these days. It's everywhere and -as I see it- it working with Axure would allow me to create high fidelity prototypes, much better than my old friend OmniGraffle. I enjoy working with wireframes, flows and solving problems. It's what I do, even more than designing. I'd like to be able to build html prototypes without the 'hassle'. (Dangerous thing to say here at HN, but I don't much like coding and html/css. I do like working with developers/frontend pro's).