Like DanielBMarkham said, the spammers are likely just looking for easy targets. So my answer to you would be "probably not."
But if we assume that they will take HN at any cost, then their course of action will match that of bacteria: attack, mutate, rinse, repeat. Eventually it will be either them or us that survives. And it probably won't be us.
More than anything else this is what will probably drive true artificial intelligence: the need for the internet to survive as a valid information and commercial platform. We're clearly setting up a prey-predator situation which will continue for as far as the eye can see.
But if we assume that they will take HN at any cost, then their course of action will match that of bacteria: attack, mutate, rinse, repeat. Eventually it will be either them or us that survives. And it probably won't be us.