I've been curious (I don't advocate trying this) as to how possible it would be to create an account for the explicit purpose of farming karma (for the minimum amount of effort) and what strategy would be best to achieve this.
Submitting random articles from favorite sites (TechCrunch, Ars Technica, TorrentFreak, etc.) as soon as they're published (i.e. before anyone else), would probably get you a few thousand Karma points in a month or two.
From my point of view however, getting good points on a comment is a lot more satisfying and worthwhile than your general Karma count (once you're over the various thresholds).