The logistics of aerial domination are pretty much the same whether you're talking drones or piloted craft. If you are the attacker you use ECM and missile/bomb bombardment to take out the radar/SAM stations. Meanwhile, you try to destroy as much of the enemy's airplanes on the ground as possible. If you have superiority in the air you take advantage of it, destroying every enemy thing that flies whether it is piloted by a crew or not.

The biggest advantage that drones have is a tactical one. And perhaps a manufacturing/logistical one if they can be produced in greater numbers, though at present that is not the case. Tactics only apply if there is a logistical balance sufficient to allow for a roughly even battlefield.

The biggest advantage of drones is you get to reuse the pilot. The second biggest advantage is you get to use a team instead of one pilot.

A key advantage is that drone pilots can learn something from having their planes blown to pieces.

To expand, I think you may be (intentionally or unintentionally) referring to loitering munitions. These are munitions (not just SAMs but other bits of kit) that are launched in theatre with no specific target set on the ground, then reconfigured in-flight after relaying information back to the ground.

Traditional SAMs aren't quite the same thing and serve different purposes.