some combination of nuclear radiation and/or solar seems like it would fit the bill? 100 years is within the useful range of a large radioisotope generator.

https://en.m.wikipedia.org/wiki/Radioisotope_thermoelectric_...

Solar would not work when you're out past Uranus or so, and the Sun is just a bright star with barely a visible disk. There's simply not enough sunlight out there, and you won't get enough light from your destination(s) star until you're similarly close to it.

RTGs lose power rapidly as the isotopes decay, and any sort of communication over those distances requires massive power. The Voyagers are essentially dead due to this issue, and they haven’t been out there nearly that long.

What about a fission reactor?

It would likely need a standalone fission reactor that only ‘goes hot’ when it arrives.

I’m not sure that we have the engineering ability to actually do that with any real chance of success after a 100 year deep space flight, or the willingness to wait that long to find out.

That runs for dozens of years without maintenance? And how do you dissipate the heat?

Open the rear end and you get propulsion as well. Just don't start close to earth

You still need matter to carry the heat, and matter is heavy (by definition!) Radiating the heat isn't going to be enough if you want to send anything other than a blob of plasma.

Which is an interesting thought when considered as a weapon. Fire a self-immolating fission reactor at your target...

I miss the days when a Bussard Ramjet was a viable dream.

Also, if there are aliens there, sending a highly radioactive blob of plasma at them at interstellar speeds might cause a little trouble.