I think it's more likely we'd see term limits and balanced budget amendments. Possibly even the power for states to override federal laws, with a supermajority.
I'd like to see other things, like the commerce clause returning to its original meaning, but like you said, it's already a high bar.
When at least 34 states call for a constitutional convention. Potentially as early as this year if at least 15 of the 21 states with proposed legislation enact the laws which call for a convention (currently 19 states have enacted laws which call for a convention). Thirty-eight states would need to ratify any proposed amendments.
The reinterpretation of the Commerce Clause was the start of a downward spiral.
I'm hoping the Convention of States will succeed and fix this, even if it means rebuilding many institutions at the State level.