My company, me as a solo dev, back in 2003-04 built a "single page app" using XUL and iframes.
Still has some 200 monthly users, the poor bastards. They have to download Firefox 3.6 iirc, and it only works in an 800x600 window.
It's a full management app for recruiting companies.
There are still 3 companies that use it (since 2008), so their employees don't have a choice really. The app does a lot, so to stop using it the companies would need to hire and migrate to 3-4 other services. I reckon SAP and the kind could do everything as well, but these companies are too small for that.
There isn't a website or anything anymore for me to show, and I haven't been involved in it for over 10 years.
XUL was beastly back then though.