Iran seemed like they were doing fine in the existence department, no? I have a lot of disagreement (to put it mildly) with Israel, but I think they'd be fine letting Iran be if they'd stop funding Hezbollah and the Houthis, and quieted down with the "Israel must be destroyed" rhetoric.
(And before the argument changes subject, I think Iran [and others] are justified in being angry with Israel about what they're doing in Gaza.)
Netanyahu has consistently said he wanted a regime change in Iran, alongside Iraq, Libya, Syria, Afghanistan. Iran does not want to end up like the other countries.
I mean, other neighboring countries close to Israel have largely made peace with the country, and they have no nukes. Iran stands out in terms of constantly funding proxies to attack it.