I think it allows very clever stuff, which I don't think is done routinely, but that's what gets talked about. I try to write clean functional style code in other languages which in my book means separation of things that have side effects and things that don't. I don't think I'll have difficulty writing standard stuff in Lisp with that approach.

Just because it allows intricate wizardry doesn't mean it is inherently hard to get/use. I think the bigger issue would be ecosystem and shortage of talent pool.