Antibiotics are not a deterrence because bacteria cannot be negotiated with. Similarly the concerns of fallout are minimal. The evolved resistance comes at a cost, evolving many resistances comes at many costs. There is a point where the bacteria cannot continue to evolve resistances yet remain competitive in the absence of the antibiotics.

AFAIK there is a new class of molecules specific to thwarting the resistance mechanism that makes the bacteria susceptible again in ways that cannot be out evolved. I'm looking for the general name for this technique - I do remember reading about it.