Yeah, the layout would still resize but it could be non-ideal in some cases as it would be based on media queries for another width.

For the rotation I could process a second layout on the background and switch to it instantly if rotated. Similarly hover effects will be limited. Things affecting visibility of the blocks/layers should work (for menus), small adjustments of layouted text too, but anything that is more complicated won't be. It currently uses a hardcoded hover effect for links.