After experiencing NixOS it's hard to settle for anything less. Nix is only good for running home-manager; nix-darwin is mostly a joke (I don't mean disrespect, I appreciate the work devs are doing, but limitations of the platform cripple the entire experience).

FWIW, Mitchell Hashimoto runs NixOS VM on his Mac for development. And that's the option I'm gonna implement once I get my MBP from repairs.