where you replace "Manhattan" with "Molecular Biology" so something in another field is going to have to really stand out (be outrageous) otherwise the reviewer will say "This isn't important enough for Science, maybe they should consider submitting the paper to Physical Review Letters instead.”
My claim is that Molbio folks see the world like
https://en.wikipedia.org/wiki/View_of_the_World_from_9th_Ave...
where you replace "Manhattan" with "Molecular Biology" so something in another field is going to have to really stand out (be outrageous) otherwise the reviewer will say "This isn't important enough for Science, maybe they should consider submitting the paper to Physical Review Letters instead.”