Biologist here. We're definitely not close to replacing animal models with software. However, many aspects of animal models can be studied using cell culture systems. I work on ovarian organoids, which can be used to develop fertility therapies.
Still, organoids will merely reduce the number of animals used in drug development rather than eliminating them entirely. Before giving a drug to humans, testing whether it's safe to give to animals is a step that can't be skipped for the foreseeable future.
I took a look at the Biogears website that you linked, and it looks like a physiology simulator, i.e. more of a model of a plumbing system than a full organism. Something that can model heart rate and blood pressure won't be able to say if a cancer drug will work (or if it will have a toxic side effect).
Most successful pre-clinical trials *fail* at predicting phase III success. The ratio is enormous. It's time to put some effort into alternative approaches.
Still, organoids will merely reduce the number of animals used in drug development rather than eliminating them entirely. Before giving a drug to humans, testing whether it's safe to give to animals is a step that can't be skipped for the foreseeable future.
I took a look at the Biogears website that you linked, and it looks like a physiology simulator, i.e. more of a model of a plumbing system than a full organism. Something that can model heart rate and blood pressure won't be able to say if a cancer drug will work (or if it will have a toxic side effect).