Good observations. There are many possible mechanisms for resistance, and with this involving bacteria I expect pretty much all are sooner or later used. Some ways are more specific to the substance, such as changing the target to fit worse or be less sensitive to the effect. Some can be quite general, such as actively pumping the molecules out of the cell.

In these cases there won't probably won't be that much wiggle room for altering the targets. Ribosomes and DNA-associated enzymes tend to be very very busy doing critical work against a lot of substrates and products, and are already heavily optimized for their normal tasks. I'd say it's no coincidence these mechanisms were chosen for a novel antibiotic attempting to mitigate resistance development.

Degrading the antibiotic, throwing it out, etc are still viable options, but it's still very nice to see someone finally trying to do this more right, even if basing it on elements of existing classes adds some risk that there are strong initialization states for resistance development out there.