"It is no measure of health to be well-adjusted to a profoundly sick society". I doubt tuberculosis is the holy grail you want it to be.

We may have enough evidence to prove there is a change, but not how the change manifests itself?

I’ve heard a similar explanation for why Goya’s imagery shifted so dramatically toward the end of his life: lead poisoning from his paints

Then it truly says something about the rest of humanity that even with tuberculosis, Orwell was a brilliant and insightful commentator on the state of the world who grasped many basic truths that elude many people even today.