If you're serving assets directly from S3 (or even from nginx) you're exposed to a "denial of wallet" attack, given the price markup on outbound networking.
So you have 10 scripts on your page, and you put them in 5 different hosts.
What does the waterfall on that look like? You're probably talking about a web app that transfers 2.6mb to the user who only wants to read 78 bytes of text. And your primary concern is the markup on outbound networking? Don't design crap pages and outbound networking isn't a problem. Most of the data transfer is fluff nobody wants or needs anyway.
You built the website! Now you don't think it's worth sending to the user? Or did you maybe go overboard when you were adding things to it?
