It has, and ironically one of those harms is that in the U.S at least ...it is still illegal or incredibly difficult to do medical studies on cannabis and it's effects because it remains a controlled substance. We need to reclassify cannabis at the federal level now so that scientists are free to do research without breaking the law.
Just today, I read some GOP members of the house want to deploy troops to Mexico as part of the war on drugs (with permission from the current Mexican government, but still a shooting war with the [other] cartels).
Way too much travel today for me to do anything more than lurk. Edited comment, apologies, I actually agree with you and completely missed the word "prohibition."