There are many different technical differences that accumulated over time - we save projects as a state snapshot, not a sequence of commands[1], we save types as semantically connected structures in a database that is guaranteed to be consistent[2], use better stack tracking for arguments and variables[3], not SP/BP/whatever, slowly migrate to a new generation of IL - RzIL instead of ESIL[4], provide standard libraries signatures out of the box in the FLIRT format[5], switched to a new way of parsing and processing commands[6], provide basefind, and many other small differences.