Reports from people using this don't indicate that they feel depressed at all. They either get a ton of nausea if their dose is too high, or they just don't get cravings to eat tons of "bad" food. Most people I've talked with on low doses report they can still eat large meals, but it has to be a pretty conscious, determined decision.

No one's been reporting depression that I've seen. And these groups ('fitness enthusiasts') experiment with enough other things that do cause depression that they're quite sensitive to changes in "well-being", "outlook on life", "mood", and "energy levels". It would be more widely reported in these circles if it did resemble depression.