Could someone who uses less regularly lay out the advantages over vanilla css? I see nesting and vender-prefix normalizing, but to me those are pretty small gains. I'm sure I'm missing something.
I mean...variables? Do you never have the same width in two places? That is so simple and so huge. Want to make your shade of green 5% darker? Don't look up a new hexadecimal, just say darken(green,5%).
Make a button "class" where the only input is a color, and it automatically generates a cross-browser rounded-corner button with a slight gradient to 10% darker color, 20% darker border, with 20% lighter inset box shadow.
I think you're right that it doesn't have built-in simplification of vendor prefixes, but they are trivial to implement into mix-ins (the example on the page you linked shows how), and I suspect it's one of the first things people set up when starting with LESS