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Elephants have 100x as many cells as a human does, live about as long, but have about 1/2 the chance of dying of cancer. Why? A big part is that each elephant cell has ~40 copies of the p53 gene.


Before anyone thinks of increasing p53 in human bodies to prevent cancer keep in mind that it can cause premature aging.


I'm sure elephants have all sorts of compensatory mutations so they can live with so many copies of the gene.




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