There's other ways to do content / ad blocking without full read/write access to every web page you visit and every network request that is made.
These other approaches do have limitations and may not be able to block everything but from a privacy perspective they are infinitely more secure than giving an extension full permissions.
> they are infinitely more secure than giving an extension full permissions
Not at all, if they can't block everything uBlock Origin can block. I trust this extension infinitely more than the websites I visit. You can even install it from the package provided by Debian in its repositories [1] if you want an extra layer of review.
These other approaches do have limitations and may not be able to block everything but from a privacy perspective they are infinitely more secure than giving an extension full permissions.