Now losing all sarcasm-detection, but perhaps not everyone realizes that that ("a show about nothing") is one of the most common/core descriptions about the original Seinfeld. "That was the joke", *swoooosh* and so on, I guess.
See [1] for instance, but it's also mentioned much earlier in the introduction section.
This is a reference to Seinfeld. When Jerry and George pitch their show to NBC, they pitch it is a "show about nothing". Which is almost like an recursion, because the show they pitch in Seinfeld is Seinfeld. So, Seinfeld is a show about nothing.
Seinfeld was about how comedians get their material, not nothing. Hence the opening, ending, and interspersed shots of Jerry doing standup related to the events in the show. Though, they somewhat dropped that in later seasons.