Syntax and layout ware worth yet a few more orders of magnitude of words. But that argument has slipped past LISPers forever. I'll just let them keep scratching their heads why Python got so popular when LISP was around for so long and is /clearly/ superior.
I don't think LISPers are scratching their head about this. Lisp syntax is optimized towards meta-programming. Generating and processing code is built-in and supported with central mechanisms: READ, EVAL, PRINT, s-expressions, macros, ...
Python is optimized towards simple pseudo-code like imperative OOP. That's easier for most programmers.