The free expansion added cloning bays as an alternative to medical bays which prevent you from healing your crew but revive them from the dead after a short cloning phase. I remember getting stuck in one situation where my O2 system was destroyed and my crew were stuck in an infinite loop of cloning and running through an oxygen-free ship in a desperate attempt to repair the life support. Funny stuff but survivable if your cloning bay is upgraded (so that it clones faster).

The hard AI is also coded to prioritise targeting your oxygen room when low on oxygen, which in various situations can cause a soft lock where you can't repair the oxygen room without dying and get stuck in the infirmary. Always hilarious when this happens.

That is just one obvious thing to do, of course. However, you need to destroy the enemy ship first. There easiest are teleportation-oriented and lasers-oriented. Teleportation oriented is extremely easy with Crystal crew, easy with mantis/rock crew, a must for 4-pad teleporter ships. Lasers oriented, best works with those lasers that use 2 power and have 3 shots, get 3 of them and enemy flagship is dead very soon. And if you are playing a drone or missile oriented game, you just need to figure out how to use the devices you happen upon on your flight to compliment your deficiencies.