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When I think of probiotics I think of this song

https://www.youtube.com/watch?v=pnJM_jC7j_4

because probiotics are the "ones that mother gives you [that] don't do anything at all"

(Right up there with Vitamin D supplements. Everything good, like low blood pressure and your team winning the Superbowl seems to be associated with high vitamin D in the population and everything bad is associated with low vitamin D... But when you supplement Vitamin D seems to lower your blood pressure as much as it makes your team win the Superbowl.)



> But when you supplement Vitamin D seems to lower your blood pressure as much as it makes your team win the Superbowl

Because you need UVA to convert the vitamin D to nitric oxide, and if you're getting enough UVA to do that then you're also more likely to already be getting enough UVB to create sufficient vitamin D in the first place.[1] Not super complicated.

Taking vitamin D supplements is probably still better than not taking them if you're deficient, but if you understand the mechanism of action then it should be obvious as to why the science is always equivocal.

[1] Or, more precisely, vitamin D regulates nitric oxide synthesis.


You need to get it from sunlight. Modern man has way too little sun exposure, and the meme of everyone being afraid of sun and using sunscreen obsessively exacerbates the problem.


You're commenting on a post about an RCT that does show probiotics having an effect...? And AIUI, there's plenty of other evidence of a) their efficacy for changing the gut biome and b) the gut biome's causal effect on a variety of health issues.


An rct with n=40 is better than the junk non-controlled studies that inexplicably get funded and accepted by journals but probably meaningless for something involving something as subjective as mental health.




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