I think we need to stop calling MRNA solutions vaccines because they are gene therapies. You need regular administration for them to be effective on a public health level which is not logistically feasible as we found out. They know this but they’re playing along as a matter of publicity and politics. We got incredibly lucky with Omicron.
The mRNA vaccines are absolutely vaccines and not gene therapies. The mRNA is turned into protein and it is that protein that your immune system is trained to attack.
If we consider mRNA, or any vaccine, to be a gene therapy it would because the immune system has to modify its own DNA to generate antibodies. But we might then call the common cold a gene therapy or becoming allergic to something an accidental gend therapy. Obviously this is silly.
The mRNA vaccines literally expose your immune system to a foreign antigen, the longstanding definition of a vaccine. They use a nice trick to get your own body to manufacture the antigen, but it's not gene therapy, they don't go anywhere your genes, they give ribosomes some extra instructions.
The boosters have been extremely effective at preventing severe infections, which is plenty useful for public health even if it isn't as good as preventing transmission entirely.
Not quite. There’s a good reason why efficacy falls off sharply after just 2-3 weeks. Again, it’s a “vaccine” not a vaccine. They just call it that because they want the public to buy-in. I say this as someone who’s been in biotech for a decade plus.
Edit: I am not antivax. I believe you should get all the shots even a second booster despite all its shortcomings.
