A quote from a Slate Star Codex[1] post that I love:
"If someone points out to you that your pet theory of the universe is in disagreement with Maxwell’s equations — then so much the worse for Maxwell’s equations. If it is found to be contradicted by observation — well, these experimentalists do bungle things sometimes. But if your theory is found to be against…thermodynamics I can give you no hope; there is nothing for it but to collapse in deepest humiliation."
"If someone points out to you that your pet theory of the universe is in disagreement with Maxwell’s equations — then so much the worse for Maxwell’s equations. If it is found to be contradicted by observation — well, these experimentalists do bungle things sometimes. But if your theory is found to be against…thermodynamics I can give you no hope; there is nothing for it but to collapse in deepest humiliation."
[1] https://slatestarcodex.com/2015/01/12/the-physics-diet/