Vanilla JS is quite nice these days, the only advantages jQuery has now is the fact that it's somewhat less verbose for DOM things and has support for old browsers.
// For example, instead of
$("#somebutton").click(() => alert("Hello"))
// You would do
document.querySelector("#somebutton").addEventListener("click", () => alert("Hello"));
// Instead of
$("#message").text("Important Message")
// You would do
document.querySelector("#message").textContent = "Important Message";
// Instead of
$("#things .thing").css("color", "red")
// You would do
for(let e of document.querySelectorAll("#things .thing")) e.style.color = "red";
// Instead of
await $.ajax("https://httpbin.org/get").then((_1, _2, {responseJSON}) => responseJSON)
// You would do
await fetch("https://httpbin.org/get").then(e => e.json())