It is definitely possible to achieve the total compensation you're looking for working remote. The companies generally fall into two categories: FAANG/MANGA/BigTechAcronymOfTheWeek companies that are remote-tolerant, and remote-first companies that are either late-stage startups or recently IPO'ed. The first category can certainly support 250k+ for an SWE at a level similar to L5 or higher. The bar will certainly be higher for the second category (as they don't have stupid amounts of money that FAANG does), so Staff+ will likely be the only positions that offer that type of compensation. Levels.fyi is a great resource to see current TC levels for offers being given by these companies.
I have been recently going down the same path you have, so I can list some options I have encountered, for whatever that may be worth:
* Coinbase
* Confluent
* Addepar
* Gemini
* Ramp
* Reddit (doesn't change compensation based on location like many companies, by the way!)
I have been recently going down the same path you have, so I can list some options I have encountered, for whatever that may be worth:
* Coinbase
* Confluent
* Addepar
* Gemini
* Ramp
* Reddit (doesn't change compensation based on location like many companies, by the way!)
* Socure
* Benchling ...