I don't know if any of the failed vaccines had antibody dependent enhancement issues but even if not it is a failure of medical ethics to not disclose the risk sufficiently since it was a risk for trial participants. This paper is not expressing concern over approved vaccines.
Yes it’s interesting that they are using previous corona profiles. You would think a yr is long enough but I’m patient and will hedge my bet by losing my job.
Previous corona profiles? The article was written before the vaccines were widely available, so the only people who had received them were in the clinical trials.
A year is absolutely long enough. To quote Derek Lowe in the "From the Pipeline" article:
"We have hundreds of millions of people who have been vaccinated to produce antibodies against the non-Delta coronavirus protein domains and are who are now being exposed to the Delta variant. To reiterate, there is (to the best of my knowledge) no evidence whatsoever of ADE in this situation. In fact, we see the opposite: people who have been vaccinated are far less likely to become infected with the Delta variant, and if they become infected, they are far less likely to experience severe disease. These trends have been seen over and over in different populations, and they are the exact opposite of what you would see if ADE were operating. If the mechanism proposed by Yahi et al. were happening in the real world, then we should see higher Delta infection rates among vaccinated people, with more severe disease. We are not. We are seeing the reverse. The vaccines simply to not appear to be causing ADE, no matter how many reasons one might be able to spin for them to do so."
