>>Now, consider what would happen if an extremely dangerous vaccine were introduced that resulted in 20 times as many AEs of all types as all the other vaccines to which it gets compared.
(emphasis added by me)
I am guessing here, but maybe the idea is that if there's an increase in AEs of all types, they're probably not caused by the vaccine.
I think the AEs are just bad things that happen after you get the vaccine, not necessarily bad things that happened because you got the vaccine.
Some places are prone to certain illnesses, and some drs/nurses are more inclined to report than others. So what they're looking for is a change in the proportion of AEs.
EDIT: I think the author might be making another mistake too:
>> Those unfamiliar with statistics will not recognize the problem, but when the different vaccines all result in similar problems (like myocarditis or blood clots, as has been noted), the chi-squared statistics will remain muted
The CDC document linked says:
>> PRRs compare the
proportion of a specific AE following a specific vaccine versus the proportion of the
same AE following receipt of another vaccine (see equation below Table 4)
The author seems to think this means "another Covid vaccine".
But just after that section, the CDC makes it clear that they really mean other vaccines in general, not other Covid vaccines:
>> CDC will apply appropriate comparator vaccines (e.g., adjuvanted vaccines like Shingrix
and/or Fluad for adjuvanted COVID-19 vaccines)
(emphasis added by me)
I am guessing here, but maybe the idea is that if there's an increase in AEs of all types, they're probably not caused by the vaccine.
I think the AEs are just bad things that happen after you get the vaccine, not necessarily bad things that happened because you got the vaccine.
Some places are prone to certain illnesses, and some drs/nurses are more inclined to report than others. So what they're looking for is a change in the proportion of AEs.
EDIT: I think the author might be making another mistake too:
>> Those unfamiliar with statistics will not recognize the problem, but when the different vaccines all result in similar problems (like myocarditis or blood clots, as has been noted), the chi-squared statistics will remain muted
The CDC document linked says:
>> PRRs compare the proportion of a specific AE following a specific vaccine versus the proportion of the same AE following receipt of another vaccine (see equation below Table 4)
The author seems to think this means "another Covid vaccine".
But just after that section, the CDC makes it clear that they really mean other vaccines in general, not other Covid vaccines:
>> CDC will apply appropriate comparator vaccines (e.g., adjuvanted vaccines like Shingrix and/or Fluad for adjuvanted COVID-19 vaccines)