I use WindowMaker with tons of custom keyboards shortcuts using the windows key : win+x to open an xterm, win+n to open a text editor, etc. I also use a lot alt+Functions keys to minimize, maximize, switch windows to back or to front... I can do about anything without ever touching the mouse. BTW a massive pain I have with Firefox 4 is that the F6 key doesn't select the URL bar anymore, this is a huge usability drawback.
I use Gnome and have set the same shortcuts, it's great but it takes a while for the file manager to open and respond, for example. Windows Explorer (especially under XP) just flies in comparison.
By the way, why are you using F6? The standard shortcut is ctrl+l, as far as I know, and it's much closer than F6.
Gnome is slow... I use Rox as a file manager. I'm used to F6 because it worked on all platforms. Ctrl+I doesn't work on a Mac. Strangely, F6 still work on the Mac, but not on Linux.
