> May be it's true that there is mRNA instability, but the efficacy data says the Moderna vaccine works extremely well
The efficacy data was based on clinical trial batches though, and the challenge seemed to be with lower manufacturing quality in the large scale commercial batches : "changes were made in their processes to ensure that the integrity was improved and brought in line with what was seen for clinical trial batches."
To be honest, we do also have real world data now (Israel mainly) that confirms the benefit/risk balance to be extremely good.
The efficacy data was based on clinical trial batches though, and the challenge seemed to be with lower manufacturing quality in the large scale commercial batches : "changes were made in their processes to ensure that the integrity was improved and brought in line with what was seen for clinical trial batches."
To be honest, we do also have real world data now (Israel mainly) that confirms the benefit/risk balance to be extremely good.