Companies can and do leverage the capital provided by their stock value, so just there would be an influence (less value = less capital = less ability to make market moves), but beyond that, I think, as others had mentioned, it could have an outsize negative psychological affect on the workforce. Plus, it could cause a feedback loop of sorts, as other investors might look at the short and jump in on the chance that someone knows something they don't, causing it to further decline, causing a multiplication on the above issues.