I'll listen when I have some time later. Does he also address the dose dependent problem in his cited studies? Of course if I'm drinking 6-7 sodas a day that's generally going to be a problem, but it doesn't mean sugar is evil. Too much water can kill me also, but I don't see people saying water is evil.
Like I said, he talks about metabolic pathways, which are independent of dose, though not your body's current state of glycogen deficiency.
He also speaks to the effect of insulin resistance, and how the very rapid metabolism of fructose in the liver (7x faster than glucose) can lead to insulin resistance. Insulin spikes redirect calories eaten directly to fat, without them ever being metabolized into energy. As a result you gain fat and have less energy available, leaving you both fatter and hungrier.
Thanks for giving such a great summation. This was the key point for me from Lustig's presentation.
Essentially, if you treat sucrose and fructose as a condiment, rather than as a key source of kCal, you will be consuming simple sugars, protein and fat, food that actually nourishes and sates you directly, versus sucrose and fructose that in high doses simply transform to fat.
Per Lustig, it's important to differentiate between starches found in bread, potatoes etc., that break down to simple sugars like glucose that are metabolized directly by the body, and added sucrose and fructose that are metabolized in the liver to fat. For people saying that our carb consumption was the same back in early 20th Century, take a look at how much of that was likely breads and the like, versus the highly sweetened cereals of today.
edit: added a para on why looking at 'carbs', misses Lustig's point.
