>The key question is "if putting a shit-ton of opioids (which already cross into the brain) in cancer patients doesn't already meaningfully treat this condition, why do we imagine that delivering the same class of drug past the blood-brain barrier suddenly will?"

It appears that as they say now that they have identified the specific mechanism of cell death that can start looking at ways to target the tumor cells without flooding the rest of the brain with loperamide or other opiates. It will be a good trick but better than the other (non) options for glioblastoma.