The bottom line? Understanding disease biology and biological networks is the rate-limiting step in revolutionizing drug discovery. No matter how well the biophysics and structural biology progresses, medicinal chemists could be targeting the wrong protein the whole time. That being said, this achievement almost seems miraculous given where we were decades ago, and it's waiting for us as we work hard to figure out the disease biology piece of the puzzle.
Yes, this 100%. Back when I started my PhD program in biophysics, the exact opposite was stated: "if you can determine the 3D structure of the protein that causes a disease, you can target it with a drug.". I wasted decades believing that paradigm because really smart people kept repeating it.
unfortunately there is no clear next step for the disease biology part of the study, as far as I can tell, except to collect enormous amounts of high quality data about diseases, typically one or a few at a time, and hope you get lucky finding something (IE, serendipity is just as important as intelligence).
